Cardiac Glycosides

Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.

Also Known As:

Glycoside, Cardiac; Glycosides, Cardiac; Steroid, Cardiotonic; Steroids, Cardiotonic; Cardiac Glycoside; Cardiotonic Steroid; Cardiotonic Steroids

Pharmalogical Action Categories:

Anti-Arrhythmia Agents
Cardiotonic Agents
Enzyme Inhibitors

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cardanolides
      - Cardiac Glycosides: 1002
Carbohydrates: 22023
- Glycosides: 2119
  - Cardiac Glycosides: 1002

Dominique G Gagnon Selected Research

Dominique G Gagnon Research Topics

Disease

Drug/Important Bio-Agent (IBA)